On 26 January 2007, Hof set a world record for fastest half marathon barefoot on ice and snow, with a time of 2 hours, 16 minutes, and 34 seconds.
In 2007, Hof climbed to an altitude of 7,200 metres (23,600 ft) on Mount Everest wearing nothing but shorts and shoes, but failed to reach the summit due to a recurring foot injury. In February 2009, Hof reached the top of Mount Kilimanjaro within two days wearing only shorts and shoes. In 2016 he reached Gilmans point on Kilimanjaro with journalist Scott Carney in 28 hours, an event later documented in the book What Doesn't Kill Us. In September, he ran a full marathon in the Namib Desert without water, under the supervision of Dr. Thijs Eijsvogels.