In 1998, Pfister shot The Hi-Line in Montana in the dead of winter on a $300,000 budget. It got into the competition at Sundance Film Festival. There, he met Nolan, who had a film at Slamdance. Pfister's first collaboration with Nolan was on the neo-noir thriller Memento (2000). The success of this collaboration resulted in Pfister taking over as director of photography for Nolan's subsequent films: Insomnia (2002), Batman Begins (2005), The Prestige (2006), The Dark Knight (2008), which he partially shot with IMAX cameras, and Inception, which was shot partially in 5-perf 65 mm. He is the only cinematographer that has worked with director Christopher Nolan between Memento and The Dark Knight Rises, and has served as cinematographer for all of Nolan's films except for Following (1998), for which Nolan acted as cinematographer himself, Interstellar (2014), Dunkirk (2017), and Tenet (2020), in those of which he was replaced by Hoyte van Hoytema, after Pfister got the chance to direct his first film, Transcendence. Pfister has stated that he "turned down many projects (including several Harry Potter films), in some cases just to be available for Nolan, or to stay home with my family."