In 2007, Santos-Recto was on her third and final term as Mayor of Lipa and was barred for seeking another term. She became a reluctant candidate for Governor of Batangas, although her brother-in-law, incumbent Vice Governor Richard Recto is seeking the governorship.
On March 5, 2007, during the regular flag-raising ceremony at the Lipa City Hall, Santos-Recto ask for a week to decide if she will run or not. This was attended by thousands of her supporters not only in Lipa but from different towns in Batangas. On March 12, 2007, she made her final decision, running for Governor of Batangas despite having her brother-in-law as her rival, including incumbent governor Arman Sanchez and former police chief Nestor Sanares.
Santos-Recto was proclaimed Governor-elect of the province of Batangas on May 21, 2007 after garnering 475,740 votes against incumbent Arman Sanchez's 344,969 becoming the first female governor of the province of Batangas. Governor Santos-Recto was reelected Governor of Batangas during the May 2010 elections defeating incumbent Santo Tomas Mayor Edna Sanchez, who substituted her husband Arman Sanchez who died on April 27, 2010, and again, reelected as Governor of Batangas during the May 2013 elections and her last term being a Governor.