Interpipe is a major producer of seamless pipes and railway wheels. In 2004, Pinchuk and Rinat Akhmetov, two of Ukraine's richest men, acquired the Kryvorizhstal steel factory for about $800 million. President Leonid Kuchma, who is Pinchuk's father-in-law, authorized the state asset sale, which competitors complained was far below market rate. Later, the first Tymoshenko government reversed this sale, and held a nationally-televised repeat auction that netted $4.8 billion. In 2006, Pinchuk founded an investment advisory company, EastOne. Its portfolio includes industrial assets such as production of pipes and tubes, rail car wheels, specialty steels and alloys, machinery, as well as media.
In 2004, Pinchuk created Yalta European Strategy (YES) – an international independent organization that is promoting Ukraine joining the European Union. Its annual summer meeting in Yalta is a Ukraine-EU forum for debate and policy recommendations development. Since the Crimean Crisis of 2014 these meetings have been taking place in Kyiv. In September 2013, Pinchuk and Tony Blair introduced Hillary Clinton's keynote address to the conference at Livadia Palace, with Bill Clinton in attendance. Stefan Fule, Paul Krugman, Alexei Kudrin, Shimon Peres, Dominique Strauss-Kahn, Larry Summers and other political and business leaders have attended. In September 2015, Pinchuk donated $150,000 to the Donald J. Trump Foundation in exchange for a 20-minute video appearance by Donald Trump shown at the conference that year in Kyiv. Michael Cohen solicited Douglas Schoen for the donation from Pinchuk, which was the largest outside donation the Trump Foundation received that year.