On 10 April 2006, the Predators announced Vokoun was afflicted by thrombophlebitis of the pelvis, a blood-clotting condition. He missed the team's remaining regular season games and the entire playoffs while he recovered by taking blood-thinning drugs and avoiding physical activity. Back-up goaltender Chris Mason took his place as the starter, but the Predators failed to advance in the playoffs, again losing in the quarter-finals. On 24 July 2006, Vokoun was cleared to resume his career and returned for the 2006–07 NHL season. However, at the beginning of the season, Vokoun injured his thumb during a game and was required to have surgery. Pins were put in this thumb, and he played with the pins and a brace on his thumb.