His breakthrough role was the bully Biff Tannen in the 1985 film Back to the Future. He returned in the sequels Back to the Future Part II and Back to the Future Part III to not only reprise his role as Biff, but to also play Biff's grandson Griff Tannen and great-grandfather Buford "Mad Dog" Tannen. In every Back to the Future film, his character ends up in a pile of manure (in reality, a heap of decayed sphagnum and other mulches) after trying to kill or hurt Michael J. Fox's character Marty McFly. He reprised his role as Biff and voiced various Tannen relatives in the animated series. Wilson did not reprise his role as Biff in the initial versions of Telltale's Back to the Future: The Game released in 2011, being replaced by Kid Beyond. When the game was ported to the PlayStation 4, Xbox 360 and Xbox One in 2015 in commemoration of the original film's 30th anniversary, Wilson returned to provide Biff's voice in these newer versions.