Susan Tedeschi was born on November 9, 1970, in Boston, Massachusetts, to a family of Italian ancestry and was raised in Norwell, Massachusetts. She is the daughter of Dick Tedeschi, granddaughter of Nick Tedeschi and great-granddaughter of Angelo Tedeschi, founder of Tedeschi Food Shops, a New England-based supermarket and convenience store chain.Tedeschi made her public debut as a six-year-old understudy in a Broadway musical. As a youth she sang for family members and listened to her father's record collection of old vinyl recordings of musicians such as Mississippi John Hurt and Lightning Hopkins. Raised as a Catholic, she found little inspiration in the church choir and attended predominantly African-American Baptist churches, feeling that the music was "less repressed and more like a celebration of God." In bands since the age of 13, she formed her first all-original group at 18, the Smokin' Section, in the nearby town of Scituate.