House's sixth novel, Southernmost was published in June 2018 and was long-listed for the Carnegie Medal for Excellence in Fiction. The book was a SIBA bestseller and received wide acclaim, especially among other writers, such as Dorothy Allison, Jennifer Haigh, Lee Smith, Garth Greenwell, and many others. It won the 2019 Judy Gaines Young Book Award, given by Transylvania University annually to recognize an excellent book from the Appalachian region.The book won the Weatherford Award for Fiction, was long-listed for the 2019 Carnegie Medal for Excellence in Fiction, and short-listed for the Willie Morris Award for Southern Fiction.
In 2018 House's novel Southernmost was long-listed for the Carnegie Medal for Excellence in Fiction and short-listed for the Willie Morris Award for Southern Fiction as well as winning the Weatherford Award for Best Novel and the Judy Gaines Young Award. In 2017 he was inducted into the Fellowship of Southern Writers. House has been awarded three honorary doctorates. His other awards include the Nautilus, the Storylines Prize, the Hobson Medal for Literature, the Intellectual Freedom Award from the National Council of English Teachers, the Appalachian Book of the Year, the Lee Smith Award, the James Still Award from the Fellowship of Southern Writers, the Jesse Stuart Media Prize, two Kentucky Novel of the Year awards, and many others. In 2016 he was invited to speak at the Library of Congress.