Kane's first play was Blasted. Kane wrote the first two scenes while a student in Birmingham, where they were given a public performance. The agent Mel Kenyon was in the audience and subsequently represented Kane, suggesting she should show her work to the Royal Court Theatre in London. The completed play, directed by James Macdonald, opened at the Royal Court Theatre Upstairs in 1995. The action is set in a room of a luxurious hotel in Leeds where Ian, a racist and foul-mouthed middle-aged journalist, first tries to seduce and later rapes Cate, an innocent, simple-minded young woman. From its opening in a naturalistic—though troubling—world, the play takes on different, nightmarish dimensions when a soldier, armed with a sniper's rifle, appears in the room. The narrative ultimately breaks into a series of increasingly disturbing short scenes. Its scenes of anal rape, cannibalism, and other forms of brutality, created one of the biggest theatre scandals in London since Edward Bond's Saved in 1965. Kane admired Bond's work, and he in turn publicly defended Kane's play and talent. Other dramatists whom Kane particularly liked and who could be seen as influences include Samuel Beckett, Howard Barker, and Georg Büchner, whose play Woyzeck she later directed (Gate Theatre, London 1997).
Skin was an eleven-minute screenplay written for Channel 4, a British TV station, depicting a violent relationship between a black woman and a racist skinhead. It was first shown at the London Film Festival in October 1995 and televised by Channel 4 in 1997. The film is directed by Vincent O'Connell and stars Ewen Bremner, Marcia Rose, Yemi Ajibade and James Bannon.