She was named to the Rogers Commission (the presidential commission investigating the Challenger disaster) and headed its subcommittee on operations. She was the only person to serve on both of the panels investigating Shuttle accidents (those for the Challenger accident and later the Columbia disaster). Following the Challenger investigation, Ride was assigned to NASA headquarters in Washington, D.C., where she led NASA's first strategic planning effort, authored a report titled "NASA Leadership and America's Future in Space" and founded NASA's Office of Exploration. After Sally Ride's death in 2012, General Donald Kutyna revealed that she had discreetly provided him with key information about O-rings (namely, that they become stiff at low temperatures) that eventually led to identification of the cause of the explosion.
Ride died on July 23, 2012, at the age of 61, in her home in La Jolla, California, seventeen months after being diagnosed with pancreatic cancer. Following cremation, her ashes were interred next to her father at Woodlawn Memorial Cemetery, Santa Monica.
Ride directed public outreach and educational programs for NASA's GRAIL mission, which sent twin satellites to map the moon's gravity. On December 17, 2012, the two GRAIL probes, Ebb and Flow, were directed to complete their mission by crashing on an unnamed lunar mountain near the crater Goldschmidt. NASA announced that it was naming the landing site in honor of Sally Ride. Also in December 2012, the Space Foundation bestowed upon Ride its highest honor, the General James E. Hill Lifetime Space Achievement Award.