Ishikawa played in PGA Tour tournaments for the first time in 2009. He was cut from the Northern Trust Open, the Arnold Palmer Invitational and the 2009 Masters Tournament. He finished 71st at the Transitions Championship.
On 28 June 2009, Ishikawa won the Gateway to the Open Mizuno Open Yomiuri Classic on the Japan Golf Tour to qualify for the 2009 Open Championship, the first major event he has qualified for without receiving a special exemption.
With four wins on the Japan Golf Tour in 2009, in September, Ishikawa became the youngest golfer ever to reach the top 50 of the Official World Golf Rankings.
At the Japan GTO awards, held in December 2009, Ishikawa earned 9 titles. In addition to top money earner, he was named MVP, best scoring average (69.93), best putting average (1.724), highest birdie haul (4.42), etc.