Following years of struggling to find a distributor and various re-shoots, Zombie confirmed that his film House of 1000 Corpses would finally be released through Lions Gate Entertainment. The film was released theatrically on April 11, 2003. The film received a generally negative reception from critics, though grossed over $16 million worldwide. The film was criticized for being too "grotesque" and "violent", but has since garnered a cult following. Despite vastly negative reviews, the film garnered a warmer reception in later years, and is frequently listed as one of the "best horror films ever made". Zombie worked with Scott Humphrey on the majority of the film's soundtrack, which was released on March 25, 2003. The release features original songs from Zombie such as "Pussy Liquor" and "Little Piggy", as well as Zombie's own rendition of the Commodores hit single "Brick House" (1977), re-titled "Brick House 2003". The soundtrack peaked at number fifty-three on the Billboard 200, and number four on the Top Soundtracks chart.
Zombie released his first compilation album, titled Past, Present & Future, on September 23, 2003. The release featured a collection of songs taken from Zombie's solo albums as well as his releases with White Zombie; new material is also present on the album. The album debuted at number eleven on the Billboard 200, and would go on to become Zombie's third release to sell over one million copies in the country. Zombie guest starred on episodes of both Spider-Man: The New Animated Series and Justice League Unlimited that year, in a voice only role for both. In November 2003, Zombie launched his Spookshow International comic book series. His second series, The Nail, spawned four issues between June and October 2004, while his Bigfoot series lasted from February to May 2005, featuring four issues. Zombie's second film, The Devil's Rejects, serves as a direct sequel to House of 1000 Corpses, and was released on July 22, 2005. The film featured a more "violent Western film" theme as opposed to the horror aspects of its predecessor. The film received a much more positive reception than its predecessor, though was still criticized for its violence and material. The film has been described as "one giant loogie that comes straight from the heart", filled with moments of nihilism and cunning wit. Much like the first film, The Devil's Rejects went on to gain a cult following after its release. The film has a 53 out of 100 rating on Metacritic, meaning mixed to positive reviews. Zombie released a number of The Devil's Rejects comics throughout 2005 to coincide with the film.