In 2014, she had two top-five UK singles; the song "I Will Never Let You Down" which debuted at number one, and she featured on Iggy Azalea's "Black Widow" which peaked at number four in the UK, and the latter became Ora's first top ten song on the US Billboard Hot 100 chart, peaking at number three. On 14 December 2014, Ora performed at the 2014 telecast of Christmas in Washington, filmed at the National Building Museum. Ora was featured on Charli XCX's "Doing It" from her second studio album Sucker. The song was released in January 2015. On 22 February 2015, at the 87th Academy Awards, she performed the song "Grateful", which appears in the film Beyond the Lights.
An appearance in an episode of the British drama series, The Brief, was her first television role, at age 13. Shortly after, she appeared in the British film, Spivs (2004). In April 2014, Ora appeared alongside Korean popstar, Hyuna, in an episode of Funny or Die called "Girl, You Better Walk." In 2015, she played Christian Grey's sister, Mia, in the film adaptation of the best-selling novel Fifty Shades of Grey, a role she later reprised in the film's two sequels. Ora originally approached the production hoping to contribute to the film's soundtrack and instead was asked to audition for the role of Mia Grey by the director of the film, Sam Taylor-Johnson.
In January 2014, Adidas announced a designer collaboration with Ora for their line of casual sports clothing, Adidas Originals. Ora designed her own apparel collections for the brand, including footwear and accessories. In 2016, she collaborated with Italian fashion brand, Tezenis, on a capsule lingerie collection. In 2018, Ora co-designed a capsule shoe collection with the Italian footwear designer, Giuseppe Zanotti. After appearing as the face of Escada, Ora co-designed her own collection with the brand in 2019.
On 15 November 2014, Ora joined the charity group Band Aid 30 along with other British and Irish pop acts, recording the latest version of the track, "Do They Know It's Christmas?", to raise money for the 2014 Ebola crisis in West Africa. On 14 November 2015, Ora performed during half-time at David Beckham's UNICEF charity "Match for Children" held at Old Trafford, Manchester. On 9 March 2016, she gave a speech on immigration and the Syrian refugee crisis at the We Day UK event in London, organised by Free the Children.