Apart from his work at Milan's Teatro alla Scala, where he was music director for 19 years, Muti has led operatic performances with the Philadelphia Orchestra and productions in the principal opera houses of Rome (from 1969), Ravenna, Vienna, London (from 1977), Munich (from 1979), and, finally, in 2010, New York. His work with the Vienna State Opera has included Aida in 1973, La forza del destino in 1974, Norma in 1977, Rigoletto in 1983, Così fan tutte in 1996 and 2008, Don Giovanni in 1999, and The Marriage of Figaro in 2001.
Muti was named conductor of the Chicago Symphony Orchestra in 2010. According to the orchestra's 2014 Form 990, he is paid a salary of $1,095,000.
In 2010, Muti wrote an autobiography. The following year, it was translated and published in English as Riccardo Muti: An Autobiography: First the Music, Then the Words. Music critic John von Rhein of the Chicago Tribune described Muti's memoir as "fascinating."