Up to the time of his illness in 2007, despite being in his seventies, Park continued to train clients at the Morningside Virgin Active Gym in Sandton, South Africa. He has been featured in many fitness and bodybuilding magazines, and has also appeared on the cover of Muscle & Fitness. He was inducted into the International Federation of Bodybuilders (IFBB) IFBB Hall of Fame's first ballot in 1999.
With his wife of 55 years, Mareon, and children Jeunesse and Jon Jon by his side, Park died on 22 November 2007 in his home in South Africa, after an eight-month battle with metastatic melanoma (a form of skin cancer). Park's legacy is continued by his son Jon Jon Park, a personal trainer and former Olympic swimmer. Reg Park raised and trained Jon Jon in South Africa. Today Jon Jon Park is the owner of the Legacy Gym, a popular gymnasium in West Los Angeles. Reg's daughter, Jeunesse, founded Food & Trees for Africa, a non profit that changed thousands of lives and landscapes.