In 1821, Cooper purchased a glue factory on Sunfish Pond on east side Manhattan Island for $2,000 at Kips Bay, where he had access to raw materials from the nearby slaughterhouses, and ran it as a successful business for many years, producing a profit of $10,000 (equivalent to roughly $200,000 in 21st century value today) within 2 years, developing new ways to produce glues and cements, gelatin, isinglass and other products, and becoming the city's premier provider to tanners (leather), manufacturers of paints, and dry-goods merchants. The effluent from his successful factory eventually polluted the pond so much that in 1839 it had to be drained and backfilled for eventual building construction.