Labelle released two more albums, Phoenix and Chameleon in 1975 and 1976, respectively. While both albums continued the group's critical success, none of the singles issued on those albums ever crossed over to the pop charts. By 1976, Patti, Nona and Sarah began arguing over the group's musical direction. Personal difficulties came to a head during a show on December 16, 1976, in Baltimore, Maryland, where Hendryx went backstage and injured herself during a nervous breakdown. Following the incident, LaBelle advised that the group separate.
In 1975, her eldest sister Vivian Hogan Rogers died of lung cancer at 43. In 1982, she lost her second-eldest sister, Barbara Holte Purifoy, to colon cancer at 40. In October 1978, she lost her mother, Bertha, to diabetes. In 1989, she lost her father Henry to emphysema brought on by complications of Alzheimer's disease and her youngest sister, Jacqueline "Jackie" Holte Padgett, to lung cancer. Like Vivian, Jackie was also only 43 when she died. LaBelle dedicated her album, Burnin' and her rendition of "Wind Beneath My Wings" in her 1991/92 concert tour to Padgett. After Padgett was gone, LaBelle shot the music video to "If You Asked Me To". LaBelle said because of her family dying early, she felt she wouldn't make it to 50 and said she felt her life was born anew after reaching that age. In 1995, LaBelle was diagnosed with diabetes. She has a home in the Philadelphia suburb of Wynnewood and also has condos in Los Angeles and in Eleuthera, the Bahamas.