In 2014, the George W. Bush Presidential Center hosted an exhibit entitled "Oscar de la Renta: Five Decades of Style" which shared the designer's creations for Mrs. Bush and America's First Ladies.
In February 2014, Oscar de la Renta recreated his entire Spring presentation, Designed for A Cure 2014 collection, to raise money for the Sylvester Comprehensive Cancer Center at the University of Miami Leonard M. Miller School of Medicine.
De la Renta died of complications from cancer on October 20, 2014, at his home in Kent, Connecticut, at the age of 82.