In early 2017, he starred in E.L. Katz's dark comedy Small Crimes which premiered at South by Southwest film festival on 11 March 2017, to positive reviews. Coster-Waldau then appeared in the Danish film 3 Things, a thriller about a prime suspect of a bank robbery who negotiates the terms of his witness protection deal. He starred in Roman Waugh's prison film Shot Caller, which premiered at the Los Angeles Film Festival on 16 June 2017. Since January 2018 he has been the L'Oréal Paris global spokesperson for the company's Men Expert line of products.
In May 2017, it was announced that he is attached to star in Domino, a film directed by Brian De Palma. The film was released on May 31, 2019. Later the same year he starred in Suicide Tourist by Jonas Alexander Arnby, which premiered at the Zurich Film Festival. Also in 2019, Coster-Waldau launched a production company named Ill Kippers. Coster-Waldau starred in The Silencing, a thriller directed by Robin Pront.
In September 2017, Coster-Waldau signed on to narrate one of the fairytales for GivingTales, the celebrity storytelling app for children and adults alike. He is going to narrate "The Steadfast Tin Soldier", on which he commented, "I am from Denmark and Hans Christian Andersen is part of our culture and I am very proud being part of this project. 'The Steadfast Tin Soldier' is a beautiful love story which we can all relate to."