In January 2013, Berkus introduced his own fabric collection at Calico Corners.
In March 2013, television journalists noted Berkus began working on a primetime series with NBC, initially titled Renovation Nation. By May 2013 the title was changed to American Dream Builders. Berkus was the host and one of the producers of the show in which, according to NBC, "American top designers, builders, architects and landscapers go head-to-head each week, putting their talents to the test on extreme home renovations." The show was not renewed after its first season.
After nearly a year of dating, Berkus became engaged to fellow interior designer Jeremiah Brent in April 2013. They were married on May 4, 2014, in Manhattan. They have two children born via surrogates: a daughter, Poppy Brent-Berkus, born on March 23, 2015, and a son, Oskar Michael Brent-Berkus, born on March 26, 2018. Berkus and his family currently live in Manhattan.