Karam was a guest performer on Star Academy 6's (Lebanon) final prime. She sang "Am Bemzah Ma'ak" (I'm joking with you), "Ta'a Khabeek" (Let me hide you), and her latest single, "Khallini Shoufak" (Let Me See you). She then appeared on Layali El Samar on 25 March 2010 on ABU DHABI TV. Also Karam was the guest star on Taratata, Dubai TV, and soon after she appeared on the TV show Akher Man Ya3lam.
On 7 May 2010 Sawt El Ghad Radio, Beirut, started playing Karam's new hit "Bil Rou7, Bil Dam" (with soul, with blood). The new hit single was the first song of Karam's that was produced directly out of Rotana in 17 years. The song, along with its video clip, which featured in it the Guinness world record for largest plate of tabbouleh, sponsored by Karam, were well received, and reached great success.
Then on 11 November 2010 Karam released her next single "Lashhad Hobbak" (I'll beg for your love). Its video clip aired on Rotana Music Channels, attracting a large audience through its classy styles, such as the spider-webbed characteristics. The song became very popular among the masses. The beaded fulle spider-web bodysuit, designed by Lebanese designer Zuhair Murad, that was worn by Karam in the video clip, was later also worn by Jennifer Lopez, in her music video, "On the Floor".
In late 2010 although there were doubts of a new contract between Karam and Rotana Production Company, after several meetings with Salem El Hendi, Karam agreed to return to Rotana. Haifa Wehbe attended the dinner party which was held after the press conference telling the press that she was glad to accept Karam's invitation and delighted to be part of the celebration.