Unamuno's dislike for Manuel Azaña's ruling went so far as to tell a reporter who published his statement in El Adelanto in June of 1936 that President Manuel Azaña should commit suicide as a patriotic act". The Republican government had a serious problem with Unamuno’s statements, and on 22 August 1936, they decreed that Unamuno should once again be removed from his position as rector of the university. Moreover, the government removed his name from streets and replaced it with the name of Simón Bolívar.
In 1936 Unamuno had a public quarrel with the Nationalist general Millán Astray at the university in which he denounced both Astray—with whom he had had verbal battles in the 1920s—and elements of the rebel movement. (see § Confrontation with Millán Astray, below) Shortly afterwards, Unamuno was effectively removed for a second time from the rectorship of the University of Salamanca. A few days later he confided to Nikos Kazantzakis:
On 12 October 1936, the Spanish Civil War had been underway for just under three months; the celebration of Columbus Day had brought together a politically diverse crowd at the University of Salamanca, including Enrique Pla y Deniel, the Archbishop of Salamanca, and Carmen Polo Martínez-Valdés, the wife of Franco, Falangist General José Millán Astray and Unamuno himself.