Papis raced in the IRL early in his career. He has raced for Roger Penske, Andretti-Green Racing and Panther Racing from 2001 to 2009. Papis is a long-time friend of drivers Tony Kanaan and Alex Zanardi. In 2013 at the Indianapolis 500, Papis and Zanardi were present in the victory celebration when Kanaan won his first Indy 500.
In 2013 at Road America, Papis, who spent nearly the entire race in the top five, found himself being spun out twice in the waning laps. When the race was over, a furious Papis went up to Billy Johnson (who spun him out one of the times) and slapped him. After being separated by officials Papis and Johnson exchanged shouts ending with Papis walking off. When he spoke to reporters, Papis apologized for the slap.
Papis drove for NTS Motorsports in the Camping World Truck Series' inaugural race at Canadian Tire Motorsport Park, the 2013 Chevrolet Silverado 250, in September 2013. Finishing 6th in the event, he was slapped following the race by the girlfriend of driver Mike Skeen, who he had crashed with on the final lap, suffering a dislocated jaw.
Also in 2013, Papis ran 4 races in the NASCAR Whelen Euro Series Elite 1 Division, he ran two races driving No. 33 Chevrolet for OverDrive team and two races driving No. 19 Chevrolet for his own team (Max Papis Racing). Papis had a best finish of 2nd at Tours Speedway.