Five years later, she made her screen acting debut for director François Truffaut in his 1962 film, Antoine and Colette. Pisier had a brief but incendiary romance with the older, married Truffaut. Despite its end, she later appeared in Truffaut's Stolen Kisses (Baisers volés, 1968) and Love on the Run (L'Amour en fuite, 1979), which was the fifth and final film in Truffaut's series about the character Antoine Doinel. Pisier was credited as a co-writer of the screenplay. In a review in The New York Times, film critic Vincent Canby praised her for a "ravishing performance".
