Though there were rumors and speculation that Janko would sign with a different club, he stayed with the Red Bulls. In 21 matches that season, Janko scored 12 goals which currently put him in second place in the Bundesliga behind teammate Roman Wallner. His best performances were a four-goal effort against FC Kärnten on 4 October, and a pair of goals scored against Josko Ried on 13 February 2010.
Janko was also an integral part of the Salzburg team that enjoyed success in its pool play in the UEFA Europa League. He had a strong performance against Standard Liège on 19 February 2010, scoring his side's two goals in a 3–2 loss in the first tie of the round of 32.
Janko signed a four-year contract with Dutch club Twente on 21 June 2010 and was given the number 21 shirt, previously worn by fellow Austrian Marko Arnautović. Twente paid Red Bull €7 million for Janko's signature.
Janko scored his first goal for his new club on 21 August 2010, his side's first in a 3–0 win over Vitesse in the third match of the Eredivisie season. In the club's next Eredivise match, Janko scored a brace and notched an assist as Twente defeated Utrecht 4–0.