On 14 March 2011, Manu scored three goals against Athletic Bilbao in only 25 minutes, one in his own net, in an eventual 2–2 home draw. He finished the season with nine goals, in a narrow escape from relegation.
On 23 May 2011, del Moral signed a four-year contract with Sevilla FC for €4 million. Following the departure of winger Diego Capel and the ageing of striker Frédéric Kanouté, he was immediately cast into his new team's starting XI. On 25 October, he hit an injury-time header to earn his side one point at home against Racing de Santander (2–2) – he had also opened the score late into the first half.
On 7 June 2011, after his best season at Getafe, del Moral made his debut for Spain, replacing David Villa during half-time of a 3–0 friendly win against Venezuela.