On April 30, 1954, KABC-TV aired a preview, Dig Me Later, Vampira, at 11:00 p.m. The Vampira Show premiered on the following night, May 1, 1954. For the first four weeks, the show aired at midnight, moving to 11:00 p.m. on May 29. Ten months later, the series aired at 10:30 p.m., beginning March 5, 1955. Each show opened with Vampira gliding down a dark corridor flooded with dry-ice fog. At the end of her trance-like walk, the camera zoomed in on her face as she let out a piercing scream. She would then introduce (and mock) that evening's film while reclining barefoot on a skull-encrusted Victorian couch. Her horror-related comedy antics included ghoulish puns such as encouraging viewers to write for epitaphs instead of autographs and talking to her pet spider Rollo.
She also ran as a candidate for Night Mayor of Hollywood with a platform of "dead issues". In another publicity stunt, KABC had her cruise around Hollywood in the back of a chauffeur-driven 1932 Packard touring car with the top down, where she sat, as Vampira, holding a black parasol. The show was an immediate hit, and in June 1954 she appeared as Vampira in a horror-themed comedy skit on The Red Skelton Show along with Béla Lugosi, and Lon Chaney, Jr.. That same week Life magazine ran an article on her, including a photo-spread of her show-opening entrance and scream. A kinescope of her The Red Skelton Show appearance was discovered in 2014. It is available as part of the Shout Factory DVD box set Red Skelton: The Early Years.
Nominated for a Los Angeles area Emmy Award as 'Most Outstanding Female Personality' in 1954, she returned to films with Too Much, Too Soon in 1958, followed by The Big Operator and The Beat Generation. Her best known film appearance was in Ed Wood's camp classic, Plan 9 from Outer Space, as a Vampira-like zombie (filmed in 1956, but released in 1959). In 1960 she appeared in I Passed for White and Sex Kittens Go to College, followed by 1962's The Magic Sword. The classic clip from Plan 9 from Outer Space featuring Vampira walking out of the woods with her hands pointing straight out was used to start the original opening sequence of WPIX Channel 11 New York's Chiller Theatre in the 1960s.