On 10 February 2006, Pavarotti sang "Nessun dorma" at the 2006 Winter Olympics opening ceremony in Turin, Italy, at his final performance. In the last act of the opening ceremony, his performance received the longest and loudest ovation of the night from the international crowd. Leone Magiera, who directed the performance, revealed in his 2008 memoirs, Pavarotti Visto da Vicino, that the performance had been recorded weeks earlier. "The orchestra pretended to play for the audience, I pretended to conduct and Luciano pretended to sing. The effect was wonderful," he wrote. Pavarotti's manager, Terri Robson, said that the tenor had turned the Winter Olympic Committee's invitation down several times because it would have been impossible to sing late at night in the subzero conditions of Turin in February. The committee eventually persuaded him to take part by prerecording the song.
Pavarotti annually hosted the Pavarotti & Friends charity concerts in his home town of Modena Italy, joining with singers from all parts of the music industry, including B.B. King, Andrea Bocelli, Zucchero, Jon Bon Jovi, Bryan Adams, Bono, James Brown, Mariah Carey, Eric Clapton, Dolores O'Riordan, Sheryl Crow, Céline Dion, Anastacia, Elton John, Deep Purple, Meat Loaf, Queen, George Michael, Tracy Chapman, the Spice Girls, Sting and Barry White to raise money for several UN causes. Concerts were held for War Child, and victims of war and civil unrest in Bosnia, Guatemala, Kosovo and Iraq. After the war in Bosnia, he financed and established the Pavarotti Music Centre in the southern city of Mostar to offer Bosnia's artists the opportunity to develop their skills. For these contributions, the city of Sarajevo named him an honorary citizen in 2006.
While proceeding with an international "farewell tour", Pavarotti was diagnosed with pancreatic cancer in July 2006. The tenor fought back against the implications of this diagnosis, undergoing major abdominal surgery and making plans for the resumption and conclusion of his singing commitments, but he died at his home in Modena on 6 September 2007. Within hours of his death, his manager, Terri Robson, noted in an e-mail statement, "The Maestro fought a long, tough battle against the pancreatic cancer which eventually took his life. In fitting with the approach that characterized his life and work, he remained positive until finally succumbing to the last stages of his illness".