In March 2019, Vanderpump opened Vanderpump Cocktail Garden located in Caesars Palace.
In June 2019, Lisa Vanderpump, longtime supporter of The Trevor Project, recorded a PSA to ensure that LGBTQ young people know they are loved, their lives have value, and are never alone.
In July 2019, Vanderpump joined Richard Ayoub, Executive Director of Project Angel Food, to countdown to Project Angel Food's 12-millionth meal in the Project Angel Food's Hollywood kitchen.
In June 2019, Vanderpump's mother Jean, died from Deep vein thrombosis (DVT).