Entering 2015, Chamberlain needed eighteen home runs to tie the all-time record. She led the team in six statistical categories, including runs, RBI, slugging percentage, and on-base percentage; she led the Big 12 conference in on-base percentage; slugging percentage; walks; and runs per game. On April 30, 2015, Chamberlain hit a grand slam in a game against North Texas pitcher Kenzie Grimes; with the home run, the 91st of Chamberlain's career, she moved into sole possession of first place all-time on the NCAA career home runs list. Following her senior season, Chamberlain was nominated for the Honda Cup Award and was named the Big 12 conference's Female Athlete of the Year. She was named to both the all-American first-team as well as the Big 12 first-team. Chamberlain retired from professional softball on May 31, 2019, prior to the NPF season.
Chamberlain was selected with the #1 overall draft pick in the 2015 NPF Draft by the USSSA Pride. In thirty-eight games with the Pride during the 2015 summer season, Chamberlain hit .205 with five home runs and eleven RBI.