In 2008, Sheard featured on Mary Mary's crossover hit, "God in Me", from The Sound album. "God in Me" became Sheard's first appearance on the US Hot 100, where it peaked at number 68. Furthermore, the single broke the Billboard record for the longest chart-run by a group and longest chart-run by a gospel song on the Hot R&B/Hip-Hop Songs chart, where it spent a total of 74 weeks and peaked at number 5. "God in Me" was also a major hit on Billboard's Dance Club and Hot Gospel Songs charts, peaking at number one on both and spending 7 consecutive weeks atop the latter. Further to this, "God in Me" won a Grammy Award for "Best Gospel Song" at the 52nd Annual Grammy Awards and was also awarded for "Outstanding Song" at the 41st NAACP Image Awards.
In October 2008, Sheard released her third album, Bold Right Life. Named after Sheard's youth organization in Detroit, the album was described by Billboard as a 'powerful mix of R&B/hip-hop, pop, rock and traditional gospel' which 'shifts from a hot uptempo beat (opener “Won’t Hold Back”) to pop (“My Boyfriend”) then to rock (“Invisible”) and traditional (“Praise Him Now”)'. The album's two lead singles were "Praise Him Now" and "Won't Hold Back". "Praise Him Now" peaked at number 7 on the US Hot Gospel Songs chart, whilst "Love Like Crazy" became Sheard's second Japanese hit, peaking at number 7 on the Japan Hot 100.