Emerson participated in the Nice's reunion tour and a 40th anniversary show for ELP, preceded by a short duo tour with Greg Lake. Apart from these reunions, he continued his solo career, releasing solo and soundtrack albums, touring with his own Keith Emerson Band, and making occasional guest appearances. Starting in 2010, he increasingly focused on orchestral collaborations. A documentary film based on his autobiography was reportedly in production at the time of his death in 2016.
Japanese composer Takashi Yoshimatsu worked with Emerson to create an arrangement of ELP's song "Tarkus", which premiered on 14 March 2010, performed by the Tokyo Philharmonic Orchestra. Yoshimatsu's arrangement has been featured in multiple live performances and two live recordings.
In September 2010, Emerson released a message stating: "During a routine medical examination, a colonoscopy revealed a rather dangerous polyp in my lower colon. It is the conclusion of the doctors here in London that I must undergo surgery immediately. Unfortunately, the timing of this urgent surgery does not allow me to start touring in early October because of the required period of hospitalization and recuperation. I must remain optimistic that all will turn out well".
In March 2010 Emerson received the annual Frankfurt Music Prize for his achievements, awarded in Frankfurt on the eve of the annual Musikmesse fair.