Karekin II was born as Ktrij Nersessian in Voskehat, Armenia, on August 21, 1951. He entered the Gevorkian Theological Seminary at Echmiadzin in 1965 and graduated with honors in 1971. He was ordained to the diaconate in 1970. Later he became a monk and was ordained a priest in 1972. In the late 1970s the Catholicos of that period encouraged him to study outside of Armenia. This led to him continuing his studies in Vienna, Bonn University, and Zagorsk, Russia. On October 23, 1983, he was consecrated bishop at Echmiadzin. He became an archbishop in 1992.