As a film and television actress, Raphael has made guest appearances on shows such as Party Down, Happy Endings, Animal Practice, American Dad!, Kroll Show, Funny or Die Presents, Big Lake, Drunk History, Flight of the Conchords, Curb Your Enthusiasm, and New Girl. She has appeared in films such as Anchorman 2: The Legend Continues, Girl Most Likely, Unfinished Business, Going the Distance, Zodiac, Bachelorette, Forgetting Sarah Marshall and Year One. In 2010, Raphael co-starred as Barb in the improvised comedy series Players on Spike TV. She also starred in all three seasons of the web series Burning Love alongside Ken Marino and Michael Ian Black.
In February 2010, Raphael joined the rotating cast of the Off-Broadway play Love, Loss, and What I Wore (written by Nora Ephron and Delia Ephron) at the Westside Theatre in Manhattan. Raphael and Casey Wilson have created their newest comedic stage show The Realest Real Housewives, which they star in alongside Jessica St. Clair, Melissa Rauch, Danielle Schneider and Morgan Walsh. The show began running monthly at the Los Angeles Upright Citizens Brigade Theatre in 2011. Raphael also contributed short stories to the 2010 book "Worst Laid Plans", based on the long-running stage show, in which she frequently performed.