On March 23, 2016 she gave her first speech at the Metropolitan Design Center (CMD) of the Buenos Aires neighborhood of Barracas, where she presented her counterpart Michelle Obama. Both First Ladies gave a talk to teens to raise awareness about the importance of education. This speech was held during the official visit made by the Obama family to Argentina on 23–24 March 2016, where they also visited the city of Bariloche, in the Argentine Patagonia.
In June 2016, the first lady welcomed the Second lady of the United States, Jill Biden, and emphasized her commitment to education and her work in defense of equal rights for women. Awada received the wife of Vice President of the United States, Joe Biden in the Presidential Residence of Olivos and shared with her then the visit to a Space of First Childhood in the locality of San Martin, Buenos Aires. After a talk they kept in the presidential villa, she invited her to visit the fifth and the organic garden that she cultivates herself in the gardens of the residence. The first lady and Minister, Carolina Stanley explained to Biden details of the objectives and role of these centers in the framework of the policy of comprehensive care for children carried out by the Government with the National Early Childhood Network. "Jill Biden is an incredible woman, who is always thinking of improving the future of the people in her community," said Awada. She emphasized that she has made "great contributions and was able to promote many positive changes from her vocation and commitment to education, her experience as a combatant's mother, her role in helping women prevent cancer and their participation for women's equality ".
In November 2016, the first lady received the spouse of the Prime Minister of Japan, Akie Abe in Buenos Aires. They shared various activities in the Buenos Aires Japanese Gardens, located in the neighborhood of Palermo, as part of the official visit by the Prime Minister, Shinzo Abe to Argentina. They witnessed a musical show of the Group of Japanese Drums-Buenos Aires Taiko of which took part members of the Band Tacuarí of the Regiment of Patricians. Later, they participated in the tea ceremony, essence of the Japanese cultural manifestations, and finally visited an exhibition of Bonsai in the facilities of that thematic garden. It was 130 years since the arrival of the Japanese community in Argentina and next year will be the 120th anniversary of the establishment of diplomatic relations.
On February 27, 2016 she met with Pope Francis at the Vatican City where she and her husband, President Macri were invited. It was the second time Awada met with the Pope, the first was in 2013 when she was the First Lady of Buenos Aires. The next day she attended a meeting between her husband and the Italian President, Sergio Mattarella at the Quirinale Palace in Rome.
In July 2016, The First Lady and the President Macri started a European tour that took them to France, Belgium and Germany, where the President sought to project his international leadership as a political and commercial partner of the European Union. Macri and Awada held in Paris a meeting with French President Francois Hollande, and Berlin with German Chancellor Angela Merkel, in this case in the context of a two-day official visit. In addition to meeting with the two leaders brunt of the European Union, the President was received in Brussels by the European Council President Donald Tusk, the High Representative of the European Union for Foreign Affairs, Federica Mogherini. The President and the First Lady were received by King Philip and Queen Mathilde at the Royal Palace of Brussels.
On September, 2016 Awada accompanied her husband to the G-20 Summit held in Hangzhou. During the summit, she fulfilled a personal agenda, on her first day visited a buddhist temple and a pedestrian street of handicrafts. At the next day she visited the Zhejiang University and participate in an activity at the China Academy of Art.
In November 2016, Awada and the Minister of Social Development, Carolina Stanley visited in the province of Córdoba an Early Childhood Space, a social dining room and a family enterprise. "Something I learned from Mauricio and the people he works with is the importance of being close to, caring for, always accompanying those who need it the most," said the First Lady. Awada also internalized on the projects of complementary financing that executed the social portfolio in order to improve the building situation and to provide equipment and supplies. President Mauricio Macri's wife stressed that the teams of workers who support these initiatives "leave everything to hundreds of children and families to have better opportunities." "Their work is very valuable. I deeply admire people who live to help others", she said.
In 2016 she was named one of the "best dressed" women in the world according to Vogue magazine. Her current style has been compared with other famous First Ladies such as Jacqueline Kennedy. Vogue Spain prepared a special issue for April issue with a particular coverage on Argentine fashion, Awada which was the main protagonist. The interview was conducted in the middle of what was BAFWEEK. The production was done in the Teatro Colón of Buenos Aires. Awada chose to wear national and Spanish designs.
She was chosen the most elegant First Lady in the world in 2016 according to the magazine ¡Hola!.