In late 2014, Mujuru was accused of plotting against Mugabe and became an outcast within ZANU-PF. She lost her positions in the party leadership at the December 2014 congress, and shortly afterward, on 8 December 2014, Mugabe dismissed her from her post as Vice-President, along with ministers who were identified with her faction. In comments published on 9 December, the same day the dismissals were announced, Mujuru said that the claims that she had plotted against Mugabe were "ridiculous".
On 10 December 2014, Mugabe appointed Mujuru's long-time rival in the succession battle, Emmerson Mnangagwa, to replace her as Vice-President.