Fatone made a cameo in February 2014 on the hidden camera show Impractical Jokers, standing in for one of the show's stars, Brian Quinn, during a challenge. He later appeared as a guest in a 2017 episode, having given permission to film at his Orlando-based hot dog restaurant Fat One's. Since 2016, he has been the host or featured guest in specials such as "Nitro Circus Spectacular", "The Joker Games", and "Fantasy Draft". He has served as the permanent host of the spin-off series Impractical Jokers: After Party since its premiere in 2017. His relationship with the show's stars also earned him a cameo in the 2020 film Impractical Jokers: The Movie.
In April 2014, Fatone began hosting the Food Network cooking competition Rewrapped, where chefs must recreate classic snack foods and then create new dishes using said snack food. In August of the same year, Fatone became the host of another series, Parents Just Don't Understand, which aired on the Hub Network prior to its rebranding as Discovery Family. He also guest starred in three episodes of The Jack and Triumph Show in 2015.