Joe Penna

On September 11, 2005, Penna launched a second YouTube channel, where he uploads his making-of videos and vlogs. Within 6 hours, it became the third most subscribed channel in Brazil.

Penna maintains the YouTube channel MysteryGuitarMan. He registered the channel on June 16, 2006.

In 2007, Penna was one of the first YouTube channels to receive mainstream media coverage, including attention from DC Fox News, after his video The Puzzle was featured on the front page of YouTube.

In 2009, Penna was again seen on the front page of YouTube with his video Guitar: Impossible, which has been covered by De Wereld Draait Door, the highest-rated primetime show in the Netherlands. On December 6, 2009, Penna was featured on FM4, an Austrian national radio station. Shortly after uploaded, his "Guitar: Impossible" video was featured on the MSN.com front page.

In 2009, Penna directed an ad in collaboration with Rhett and Link entitled T-Shirt War. It garnered international attention. Shortly after, Penna was selected as one of the top 10 new directors at the 20th Cannes Lions Saatchi & Saatchi New Directors' Showcase.

In 2010, Penna's Root Beer Mozart"l was featured on CNN's morning show Morning Express with Robin Meade and on Germany's nationally broadcast Taff show.

In June 2010, Penna was highlighted by CNN Money on their Best Jobs series.

By January 2011, MysteryGuitarMan became the most subscribed channel in Brazil. As of January 2019, his channel has garnered over 2.7 million subscribers, and his videos have accrued nearly 400 million views.

In 2012, Penna co-wrote and directed an original interactive thriller series entitled Meridian, starring Orlando Jones and Rick Overton in conjunction with Fourth Wall Studios.

In August 2014, Penna was announced as the host of Xploration Earth 2050, a technology-oriented television series. Xploration Station went on to receive eight Daytime Emmy Award nominations.

In March 2016, his short film Turning Point was selected to play at the Tribeca Film Festival.

In February 2017, Penna began production of his directorial debut feature film, Arctic. It was shot in Iceland and stars Mads Mikkelsen. Arctic garnered enthusiastic reviews as an Official Selection for the 2018 Cannes Film Festival. Its theatrical premiere was on February 1, 2019.

In June 2019, Penna began shooting on the sci-fi movie Stowaway starring Anna Kendrick and Toni Collette.