In her son’s novel Kentucky Ham (1973), Vollmer is remembered as a gentle and considerate mother who was meek and deferential to her husband's parents. Yet she is also depicted as being prone to wild bouts of self-destructive behavior. The book recounts a reckless, almost deadly drive down a mountainside road in Mexico. Joan's battered appearance and unpredictable behavior alarmed Ginsberg when he visited with Lucien Carr in 1951. During their visit she expressed some bitterness and hostility toward Burroughs' lack of affection and continued drug addiction. In fact, at the time of Ginsberg's visit, Burroughs was away in Guatemala with a young man he pursued unsuccessfully.
On September 6th, 1951, Burroughs shot Vollmer in the head, allegedly while trying to shoot a glass he had asked her to balance on her head during a drunken William Tell act. Vollmer died several hours after being shot in the head, at the age of 28. Burroughs said he had eight to ten drinks and couldn't remember much of that night, while witnesses Woods and Marker claimed they had two small glasses. The couple's four-year-old son, William Burroughs Jr. was in the room when the accident occurred. Burroughs gave different accounts of the shooting, denying his original William Tell story after intervention by his prominent Mexican attorney, Bernabé Jurado.
Friends of the couple were divided in opinion on the case. Ginsberg and Carr defended Burroughs and believed that Vollmer may have encouraged the William Tell incident, stating she had seemed suicidal when they visited her in 1951. Haldon Chase, who had also visited Burroughs and Vollmer in 1951 in Mexico City, distanced himself from Burroughs after Vollmer's death. Chase believed that Vollmer "had wanted to die," but that Burroughs story was "a sham, a put-up thing to release Bill, to let him commit the ultimate crime." In interviews with Ted Morgan from 1983-1986, Burroughs said "Allen was always making it out as a suicide on her part, and I do not accept that cop-out." By the 1980s, Burroughs had publicly returned to the William Tell story to explain the killing of Joan.
The film Beat (2000) is a biographical account of the relationship between Joan Vollmer Burroughs and William S. Burroughs. Joan Vollmer Burroughs is portrayed by Courtney Love and William S. Burroughs by Kiefer Sutherland. There are brief appearances by Daniel Martinez as Jack Kerouac, Ron Livingston as Allen Ginsberg and Norman Reedus as Lucien Carr. The film centres on the killing of Joan Vollmer Burroughs, on 6 September 1951, by her husband, William S. Burroughs. It also portrays Lucien Carr's plea of guilty to the first-degree manslaughter, on 13 August 1944, of David Kammerer, played by Kyle Secor, for which he served two years of a one-to-twenty-year sentence in the Elmira Correctional Facility in Upstate New York.