In 2010, Loyden was the starting goalkeeper for the Chicago Red Stars in the Women's Professional Soccer league, playing in 23 games while making 72 saves and compiling a 1.17 GAA.
Loyden made her first appearance for the United States women's national soccer team on October 2, 2010 in a game against China. In 2011, she earned a spot on her first world championship roster, making the Women's World Cup team as the third goalkeeper.