In 2011, she appeared on Portlandia in comedic skits with Fred Armisen and Carrie Brownstein. She played a musician who unsuccessfully tries to play at every venue of a festival as a member of the band Sparkle Pony, and is turned away as she is not on the line up of any of them.
She is married to drummer Steve Drizos. In May 2011, Conlee was diagnosed with breast cancer. Colin Meloy said that a full recovery was likely, but that she would miss some concerts. On October 20, 2011, Meloy announced via his Twitter that Conlee's cancer was in remission.