He finished 2006 as the No. 2 Serbian tennis player after Djokovic, and he was ranked in the top 100 for the first time at No. 65. He won four Challenger titles, compiling a 31–8 record at that level. On the ATP Tour, he reached the quarterfinals of the Nottingham Open, losing to Robin Söderling from Sweden.
Tipsarević was born in Belgrade, Serbia (then SFR Yugoslavia). His father, Pavle, is a professor, and his mother, Vesna, is a housewife. He also has a younger brother, Veljko (Вељко). He finished high school and in 2006 completed his degree in Sports Management at the University of Belgrade.