In June 2008, Oliver launched a restaurant, Jamie's Italian, his first high street business venture, in Oxford, England. At its peak, there were 42 Jamie's Italian restaurants in the UK. The brand was franchised and includes branches in the UAE, Australia (which Oliver part-bought back in November 2016 after its founders went bankrupt), Canada, Cyprus, Iceland, Ireland, Russia, Turkey, Singapore and Hong Kong.
Oliver's Ministry of Food campaign began in 2008 with the Channel 4 series of the same name and the opening of the first Ministry of Food Centre in Rotherham. More MoF Centres have since opened in Bradford, Leeds, Newcastle/North-East, Stratford (now known as Food Academy) and Alnwick. Ministry of Food Centres and trucks have opened in Australia in Ipswich, near Brisbane and Geelong, Melbourne. State governments in Australia provided funding for these Centres.
Oliver is the second British celebrity chef (after Robert Irvine) to appear as a challenger on Iron Chef America, taking on Iron Chef Mario Batali in 2008 in a losing battle with cobia as the theme ingredient.
Oliver was one of the judges in the Oprah's Big Give hosted by Oprah Winfrey in the United States in 2008.