Straczynski wrote Changeling, a psychological drama film based partly on the "Wineville Chicken Coop" kidnapping and murder case in Los Angeles, California. Directed by Clint Eastwood, produced by Ron Howard, and starring Angelina Jolie, the film premiered in 2008 and subsequently received eight nominations for the BAFTA Award, including a nomination for Best Original Screenplay. The first draft script was written in eleven days, after Straczynski figured out "how to tell" the story, which ended up being the shooting draft, after Eastwood declined to make any changes. It was optioned immediately by Howard, who at first intended to direct the film but later stepped down after scheduling conflicts.
In 2008, Straczynski wrote a draft of Ninja Assassin for Joel Silver, which he completed in just 53 hours. The film was produced by the Wachowskis and released on November 25, 2009.
In June 2008, Daily Variety named Straczynski one of the top Ten Screenwriters to Watch. They announced Straczynski was writing Lensman for Ron Howard (to whom he had sold a screenplay entitled The Flickering Light), that he was selling another spec, Proving Ground, to Tom Cruise and United Artists. In October 2008, it was announced that Straczynski was engaged to pen a remake of the science fiction classic Forbidden Planet. In the fall of 2009, it was reported that Straczynski was writing a movie titled Shattered Union for Jerry Bruckheimer and Disney. The screenplay, based on the video game of that name, concerns itself with a present-day American civil war.