Coronel was killed on 29 July 2010, in Zapopan, Jalisco, during a shootout with the Mexican Army. During the raid, Coronel killed a soldier and wounded another. A statement from the federal Attorney General's Office says soldiers found jewelry, luxury watches, guns, two hand grenades and three vehicles and US$7 million in cash in the house where Coronel was killed.
On 3 April 2010, alleged gunmen of Los Zetas abducted and killed Coronel's son, Alejandro Coronel (aged 16), in Bahía de Banderas, Nayarit. Ignacio sought vengeance and responded three days later by sending over 100 of his henchmen to kidnap and kill 14 people.
A few days after Coronel was killed on 29 July 2010, his nephew Mario Carrasco Coronel ("El Gallo") was killed by the special forces of the Mexican Army in Guadalajara, Jalisco. Mario reportedly aided his uncle Ignacio directly in the cartel activities and was his alleged successor.
In January 2010, several members of the Coronel clan were arrested: Ernesto Coronel Peña, Juan Jaime Coronel, Juan Ernesto Coronel Herrera, and Gael Carbel Aldana. His cousin José Ángel Coronel Carrasco ("El Changel") was arrested by Mexican soldiers in Culiacán on 20 January 2013. He was the successor of Coronel Villarreal and top leader of La Corona Cartel, a Sinaloa Cartel-affiliated gang founded between late 2012 and early 2013.