Horatio Sanz

Sanz joined the cast of Saturday Night Live in September 1998 as the first Hispanic cast member. At the beginning of SNL's 31st season, he was the temporary replacement for Tina Fey as Amy Poehler's Weekend Update co-anchor while Fey was on maternity leave until she resumed her duties on October 22, 2005. On September 20, 2006, SNL announced that Sanz would not be returning due to massive budget cuts that called for Lorne Michaels to either produce fewer episodes or reduce expenses, including the paring of long-standing, highly paid cast members such as Sanz.

Sanz returned to SNL as a guest on February 3, 2007, appearing as Elton John, and on November 3, as presidential candidate Bill Richardson and again on the December 17, 2011 Christmas show as himself in a musical number ("I Wish It Was Christmas Today") and as a member of Beethoven's orchestra ("Beethoven: Meet The Band").

In November 2008, Sanz made his first public appearance in almost a year, after having lost 100 pounds (45 kg; 7 st 2 lb). "I've been eating better", Sanz said. "I've been trying to come up with a joke about how I've lost weight and I was going to say, 'I stopped putting nuts in my sundaes.'" He also says, "I never weighed myself when I was at my fattest, because I was scared I might die'." Sanz says he has been working out, too. In June 2009, he appeared on Late Night with Jimmy Fallon and said that much of his weight loss was because he had stopped drinking alcoholic beverages.

Sanz was part of the cast of the short-lived ABC sitcom In the Motherhood in 2009, playing the role of Horatio the "manny" (male nanny). In 2010, Sanz and his former SNL castmate Chris Parnell starred together on Big Lake, a Comedy Central sitcom from executive producers Will Ferrell and Adam McKay. From 2010 to 2011, Sanz was a writer and producer on the Comedy Central sketch series Nick Swardson's Pretend Time.

In 2015, he started his own podcast called The Hooray Show, which features comedy sketches and interviews with his friends in comedy.

He became an American citizen on July 25, 2018 in Los Angeles.