As of 2017, Wyss and the Wyss Foundation have donated more than $350 million to environmental protection, including conservation of national forests and other public lands in the Western United States.
The Wyss Foundation's landscape protection strategies have included assisting the purchase of mineral leases from oil and gas companies. Other causes the Wyss Foundation supports includes river restorations, ocean conservation in Peru and Canada, anti-poaching efforts in Africa, and environmental journalism. In 2017, the organization announced a charitable commitment of $65 million to African Parks, a conservation NGO overseeing ten parks in seven African nations, to help create new protected areas in Africa.
As of 2017, Wyss ranks 281 on the Forbes list of billionaires, with an estimated net worth of approximately $5.5 billion. He ranks number 235 on the Bloomberg list of billionaires.