Regardless of the mixed reviews, Fuerza Natural entered the charts in Argentina, Mexico, and Chile at No. 1. It is the first Cerati album to be sold in digital format in Argentina through MusicPass as well as was iTunes. The album sold 40,000 copies in Argentina on its first week of release and 500,000 albums worldwide. In 2010 Cerati was awarded a Latin Grammy for "Best Rock Song."
The Fuerza Natural tour kicked off on 19 November in Monterrey Mexico. Cerati played Stadiums and large venues in Mexico, Argentina, Peru, Chile, The United States, Uruguay, Colombia and Venezuela, 21 shows in total. Cerati's final show was held in Caracas, Venezuela on 15 May 2010. Cerati suffered a stroke immediately after the show.
After performing two shows in Medellín and Bogotá, Colombia, Cerati headed to Venezuela and performed one last show in Caracas on 15 May 2010. Cerati suffered a stroke just after putting an end to this performance. He developed the first symptoms of an unknown condition backstage. He was hospitalized in Centro Médico La Trinidad in Caracas under medical surveillance. Three days later, Cerati underwent surgery to relieve pressure on his brain due to the stroke he suffered.
On 7 June 2010, Cerati was transferred to the FLENI Neurological Institute in Buenos Aires. Doctors immediately treated Cerati for a respiratory tract infection. The following day, doctors reported extensive brain damage due to the stroke. Cerati fell into a coma sometime before. He was maintained on life support hoping for a recovery. A month after the stroke, Claudio E. Pensa M.D., medical director of the FLENI Neurological Institute, issued a statement to the press stating that Cerati's medical condition remained unchanged and that he would only provide new information if changes were to occur. On December 2, 2010, a statement was issued by ALCLA Clinic's medical director stating that, neurologically, Cerati was reacting to thermal stimuli.
While performing at Rock in Rio Madrid on 5 June 2010, Colombian singer Shakira dedicated her song "Sale el Sol" to Cerati. It was her first live performance of the song which became the title track of her ninth studio album.