In 2012, Karimova was honoured with the "Silk Road and Humanitarian Cooperation" Award of the Shanghai Cooperation Organization.
In April 2012, Karimova announced that she had initiated the establishment of a new NGO, the "Forum of Socially Responsible Citizens of Uzbekistan", which focuses on support of Uzbek citizens' social initiatives.
In December 2012, Googoosha released a duet with French actor Gérard Depardieu. During his visit to Uzbekistan, the French actor agreed to star in an Uzbek film. Gulnara Karimova wrote a screenplay for "The Theft of the White Cocoon," a story about the origin of the famed Central Asian silk, and set in the 5th and 6th centuries.
Googoosha's first single "Round Run" was released in April 2012, with various remixes by DJ White Shadow, Razor N Guido of USA and Max Fadeev of Russia. In June 2012 Karimova released her self-titled debut album in the US and other countries on iTunes. The album was also expected to be released in Asia, Russia and a number of other European countries. However, early reviews by critics have panned the debut album thus indefinitely halting the release in those markets.