Lopez has a genetic condition that caused his kidneys to deteriorate. His doctors had told him in April 2004 that he was going to require an organ transplant but he postponed the operation until finishing the fourth season of George Lopez. In 2005, his wife Ann donated one of her kidneys to Lopez. The transplant was successful; Lopez lost 45 lb (20 kg) after the operation due in part to the improvement in his health. He brought awareness to the issue on his show; his character's son Max was diagnosed with a similar illness.
Lopez was a featured celebrity golfer in the 2004 Bob Hope Chrysler Classic and the 2004 AT&T Pebble Beach National Pro-Am. Lopez and his pro partner finished third in the Pebble Beach event. George was the top-ranking celebrity at completion of the tournament. Since 2006, Lopez has served as host of the Bob Hope Chrysler Classic. He is a member at Lakeside Country Club in Burbank, California, and has a 13 handicap.
A native of Los Angeles who grew up in the San Fernando Valley's Mission Hills, Lopez devotes much time to the community. He heads his own charity, The Ann & George Lopez Foundation (www.thelopezfoundation.org). He is a recipient of the Manny Mota Foundation Community Spirit Award and was named Honorary Mayor of Los Angeles for his extensive fund-raising efforts benefiting earthquake victims in El Salvador and Guatemala. In February 2004, Lopez was presented the 2004 Artist of the Year and Humanitarian Award by the Harvard Foundation at Harvard University, presented by its president and dean for his artistic work and charitable endeavors.
Lopez has received several honors for his work and contributions to the Latino community. In September 2004, George was honored with the "Spirit of Liberty Award," presented by People for the American Way. In August 2005, Time magazine recognized George as one of "The 25 Most Influential Hispanics in America." On October 18, 2011, Lopez's elementary school, San Fernando Elementary School, honored him for his beneficent efforts by naming their auditorium after him. Lopez has ensured through his annual toy giveaway that every child at the school receives a gift during the holidays.